Cities as Living Labs : Increasing the impact of investment in the circular economy for sustainable cities

Aim of the study. From innovation system and policy development point of view, it is vital to understand the impact and added value of EU-funded projects especially in context of the complex societal challenges such as circular economy in cities. By definition Circular Economy (CE) promotes resource minimisation and the adoption of cleaner technologies while maintaining the value of products, materials and resources in the economy for as long as possible and minimizing waste generation. Living Lab (LL) is an open innovation ecosystem based on a systematic user co-creation approach that integrates public and private, research and innovation activities in communities, placing citizens at the centre of innovation with the help of various approaches, instruments, methods, and tools

Prevalence and Impact of Rheumatologic Pain in Cystic Fibrosis Adult Patients

International audienceBackground With the improvement of cystic fibrosis (CF) patient survival, the prevalence of long-term complications increased, among them rheumatologic disorders.Methods The aim of this prospective study was to evaluate the prevalence of spinal and joint pain, and their impact on disability, anxiety, depression, and quality of life in CF adult patients.Results Forty-seven patients were analyzed, 72% of men, mean aged 28 years, with a mean body mass index of 22 kg/m 2 and a mean FEV 1 % of 63%. Twenty-two patients (47%) described rheumatologic pain either spinal ( n = 15, 32%) and/or joint pain ( n = 14, 30%). Patients with spinal and/or joint pain were shorter ( p = 0.023), more frequently colonized with Staphylococcus aureus ( p < 0.008), had more frequent ΔF508 homozygous mutations ( p = 0.014), and a trend for more impairment of the 6-min walking distance ( p = 0.050). The presence of rheumatologic pain tended to be associated with disability according to the Health Assessment Questionnaire (HAQ) and anxiety. Compared with patients with no pain patients with both spinal and joint pain exhibited a more pronounced impact on the St George's Respiratory Questionnaire (SGRQ).Conclusion Rheumatologic pain is frequent in CF adult patients, and may affect daily living, anxiety and quality of life. Systematic assessment of rheumatologic pain should be included in the management of CF patients